Dr. Marco Marino

Curriculum Vitae

Dr Marco MARINO
Medical Doctor
Specialist in Gastroenterology

Personal Details

• Name: Marco MARINO
• Address: 33100 Udine, Italy
• Telephone: 0039 0432 559065
• Cellular Phone: 0039 347 2444039
• Date of Birth: 21/03/69
• Nationality: Italian
• Race: Caucasian
• Place of Birth: Naples (Italy)
• UK GMC Registration No.: 4656962 (since 20 AUG 1999)
• CCST in Gastroenterology: 04/11/2003 (Medical School – University of Udine, Italy)
• Codice Fiscale: MRNMRC69C21F839A

Memberships

Member of: AIGO (Italian Association of Italian Gastroenterologists) and regional elected president 2012-2014, ECCO (European Crohn’s and Colitis Organisation), BSG (British Society of Gastroenterology).

Education

• School: 1982-1988 Classical Gymnasium (High School)
• University: 1991-1998 Medical School of Udine (Italy)
• 1998 Graduated in Doctor in Medicine and Surgery
• 1999 Italian Full Registration as a Medical Doctor
• 1999 Full Registration at the GMC with No 4656962
• Clinical School: 1999-2003 Higher Specialist Training in Gastroenterology at the University Medical School of Udine (Italy)

Post Registration Qualifications

• July 1999 Italian Full Registration as a Medical Doctor
• 20/08/1999 Full Registration at the British General Medical Council with No 4656962
• 4/11/2003 Italian Certificate of completion of specialist training in Gastroenterology

Life Support Courses

1995-2013 Regular BLS every two years (last on 2014)

Practice History

Present Appointment

• From 2020 Coordinator of the IBD Unit at University Hospital of Udine
• From 05/11/2003 Full time Consultant Specialist in Gastroenterology at the General Hospital-University of Udine with permanent position (Italy)
• 05/11/2003 CCST in Gastroenterology in Italy

Medical Training

• November 2007 Clinical stage at University Hospitals of Leicester NHS Trust - Digestive Diseases Centre at the Leicester Royal Infirmary
• 01/10/1999–11/4/2003 Higher Specialist Training in Gastroenterology at the Medical School of Udine. During this period attended wards and endoscopic room of: General Hospital of Udine (Italy), General Hospital of Pordenone (Italy) and General Hospital of Gorizia (Italy).
• Basic research: biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and evaluation of their role in experimental and human cholestasis. Identification of genetic patterns determining susceptibility to gallstone formation via an increased secretion of biliary lipids.
• 30/11/2002-3/11/2003 Specialist Registrar in Gastroenterology at the General Hospital of Pordenone (Italy)
• 2/11/2002- 10/01/2002 Specialist Registrar in Gastroenterology at the General Hospital of Gorizia (Italy)
• 1/10/1999-09/01/2002 Specialist Registrar in Gastroenterology at the General Hospital of Udine (Italy)
• 06/01/1999-30/11/1999 Temporary Substitution of GP in Italy
• 20/08/1999 Full Registration at the GMC with No 4656962
• 08/23/1998–05/25/1999 Pre-registration house Officer at the Medical School of Udine and at the General Hospital of Udine (Italy)

Practical Procedures

I am competent in the following:

Anaesthesia

Simple and advanced sedation (benzodiazepine, opioids)

Endoscopic Procedures

• Diagnostic and operative esophagogastroscopy (over 8000 procedures)
• Diagnostic and operative colonoscopy (about 5000 procedures, over 95% cecum intubation) with almost 100% of retrograde ileum intubation when needed
• Operative endoscopy:
  • Lower and upper gastrointestinal dilatation of neoplastic and non-neoplastic strictures (mechanical and pneumatic): about 200 procedures
  • All hemostasis techniques in upper and lower GI bleeding (variceal and non-variceal): thermal (bicap, APC and heat probe), injection (adrenaline, atoxisclerol, fibrin glue and acrylate polymers), mechanical (endoclips)
  • Esophageal Band Ligation: over 400 procedures
  • Removal of ingested foreign bodies: 70
  • Debulking of GI cancers (thermal therapy with lasers and APC)
  • Percutaneous Endoscopic Gastrostomy: over 250 procedures
  • Lower and upper endoscopic polypectomy and endoscopic mucosal resection: about 2800 procedures
  • Gastrointestinal stenting, upper and lower GI tract
  • Full proficiency in capsule endoscopy and diagnostic and operative single balloon enteroscopy (Olympus)
  • Since 2008 full proficiency as endoscopist for the colon cancer screening program in Italy

Surgical Procedures

• Wound toilet and suturing (during E.R. fellowship)

Miscellaneous

• Diagnostic and operative paracentesis

Special Interests

Inflammatory Bowel Disease, gastrointestinal GVHD, colon cancer, GERD & BE, functional disease, coeliac disease, endoscopic palliation of GI cancers

Languages

Italian: mother tongue
English: written and spoken - good level

Computer Skills

Familiar with both PC and Apple and related programs

Teaching

From 2007 until now: Invited Lectures (to medical students and registrars) at the University of Udine Medical School

Publications

Full Papers

1. Parisi G, Bottona E, Carrara M, Cardin F, Faedo A, Goldin D, Marino M, Pantalena M, Tafner G, Verdianelli G, Zilli M, Leandro G. Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial. Dig Dis Sci. 2005 Jun;50(6):1107-12.
2. Maieron R, Elli L, Marino M, Floriani I, Minerva F, Avellini C, Falconieri G, Pizzolitto S, Zilli M. Celiac disease and intestinal metaplasia of the esophagus (Barrett's esophagus). Dig Dis Sci. 2005 Jan;50(1):126-9.
3. Stefano Passalacqua, Pietro Manuel Ferraro, Giampaolo Bresci, Valeria D'Ovidio, Marco Astegiano, Mariabeatrice Principi, Roberto Testa, Renata D'Incà, Daniela Valpiani, Alessandro Armuzzi, Renato Sablich, Flaminia Cavallaro, Francesco Costa, Vincenza Di Leo, Elisabetta Colombo, Alessia Santini, Annalisa Aratari, Pierenrico Lecis, Valeria Saladino, Gabriele Riegler, Marino Marco, Francesca Calella, Chiara Ricci, Maria Luisa Guidi, Giuseppe Repaci, Michele Silla. The Italian Registry of Therapeutic Apheresis: granulocyte-monocyte apheresis in the treatment of inflammatory bowel disease. A multicentric study. J Clin Apher. 2011 Dec;26(6):332-7.
4. Faleschini G1, Vadalà di Prampero SF, Bulajic M, Baccarani U, Toniutto P, Panic N, Zoratti LM, Marino M, Zilli M. Predictors of endoscopic treatment outcome in the management of biliary complications after orthotopic liver transplantation. Eur J Gastroenterol Hepatol. 2015 Feb;27(2):150-4.
5. Sorrentino D, Marino M, Dassopoulos T, Zarifi D, Del Bianco T. Low Dose Infliximab for Prevention of Postoperative Recurrence of Crohn's Disease: Long Term Follow-Up and Impact of Infliximab Trough Levels and Antibodies to Infliximab. PLoS One. 2015 Dec 15;10(12):e0144900. doi: 10.1371/journal.pone.0144900. eCollection 2015
6. Frossi B, Tripodo C, Guarnotta C, Carroccio A, De Carli M, De Carli S, Marino M, Calabrò A, Pucillo CE. Mast cells are associated with the onset and progression of celiac disease. J Allergy Clin Immunol. 2016 Sep 13. pii: S0091-6749(16)30948-4
7. Brian G. Feagan, M.D., William J. Sandborn, M.D., Christopher Gasink, M.D., Douglas Jacobstein, M.D., Yinghua Lang, M.A., Joshua R. Friedman, M.D., Ph.D., Marion A. Blank, Ph.D., Jewel Johanns, Ph.D., Long-Long Gao, Ph.D., Ye Miao, M.S., Omoniyi J. Adedokun, M.S., R.Ph., Bruce E. Sands, M.D., Stephen B. Hanauer, M.D., Severine Vermeire, M.D., Ph.D., Stephan Targan, M.D., Subrata Ghosh, M.D., Willem J. de Villiers, M.D., Ph.D., Jean-Frédéric Colombel, M.D., Zsolt Tulassay, M.D., Ursula Seidler, M.D., Bruce A. Salzberg, M.D., Pierre Desreumaux, M.D., Scott D. Lee, M.D., Edward V. Loftus, Jr., M.D., Levinus A. Dieleman, M.D., Ph.D., Seymour Katz, M.D., and Paul Rutgeerts, M.D., Ph.D., for the UNITI–IM-UNITI Study Group. Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease. N Engl J Med 2016; 375:1946-1960. November 17, 2016. UNITI-1 Investigators (UNITI-1 Study Group) IM-UNITI Investigators (IM-UNITI Study Group): Dr Marco Marino
8. Vadala di Prampero S, Marino M, Toso F, Avellini C, Nguyen V, Sorrentino D. Isolated Bilateral Gastrocnemius Myositis in Crohn Disease Successfully Treated with Adalimumab. Case Rep Gastroenterol. 2016 Nov 7;10(3):661-667
9. Panic N, Macchini F, Solito S, Boccia S, Leoncini E, Larghi A, Berretti D, Pevere S, Vadala S, Marino M, Zilli M, Bulajic M. Prevalence of Extrapancreatic Malignancies Among Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas. Pancreas. 2018 May 17. doi 10.1097/MPA.0000000000001072
10. Vadalà di Prampero, Solito S, Faleschini G, Panic N, Castriotta L, Picci A, Pinese E, Piva R, Bulajic M, Marino M, Rossitti P, Zilli M. The Impact of Dietician Support and Behavioural Therapy in Addition to Concomitant Treatment with Intragastric Balloon in Obese Patients. Obes Surg. 2020 Feb;30(2):612-617
11. Rossana Domenis, Marco Marino, Adriana Cifù, Giulia Scardino, Francesco Curcio, Martina Fabris. Circulating exosomes express α4β7 integrin and compete with CD4+ T cells for the binding to Vedolizumab. PLoS One. 2020; 15(11): e0242342. Published online 2020 Nov 12. doi: 10.1371/journal.pone.0242342

Abstracts

1. M Marino, Brosolo P, Minerva F, G De Pretis. Granular Cells Tumor Of The Esophagus (Abrikossoff’s Tumor) – Endoscopic, Echo-Endoscopic And Clinical Aspects. GEEMO Meeting 2001 & Postgraduate Course On Esophageal Disease.
2. Dado G, Bresaola V, Terrosu G, Marino M, Scanavacca F, Benzoni E, Zilli M, Bresaola F. Laparoscopic treatment in unknown cholelithiasis. 7° National Congress of Italian Society of Laparoscopic Surgery, 2001.
3. Brosolo P, Marino M, Minerva F, Maieron R, Avellini A, De Pretis G. Endosonographic diagnosis of Gastric Linitis Plastica”. 9th United European Gastroenterology week. Endoscopy; Vol 33 (Suppl I); November 2001; abstract n° 1939
4. Maieron R, Marino M, Minerva F, Brosolo P, Pizzolitto P, Avellini A, Beltrami B, De Pretis G. Short-Segment Barrett’s Esophagus (SSBE): clinical, endoscopical and histological data. Endoscopy; Vol 33 (Suppl I); November 2001; abstract n° 2081
5. Maieron R, Marino M, Minerva F, Brosolo P, Macor C, Zoratti L, Andreoli S, Zilli M. Short-Segment Barrett’s Esophagus (SSBE): clinical, endoscopical and histological data. 7th National Congress of Digestive Diseases, Bari (Italy), 2001. Digestive and Liver Disease; Vol 33 – supplement number 1 – November 2001 – abstract 92
6. Elli L, Maieron R, Marino M, Panos J, Andreoli S, Macor C, Zoratti L, Berretti D, Zilli M. Celiac disease and intestinal metaplasia of the oesophagus. 8th National Congress of Digestive Diseases. 22-26 June 2002, Rome, Italy. Abstracts of Scientific Presentations. Digestive and Liver Disease 2002, vol. 34, suppl.1, A28.
7. Carrella M, Elli L, Panos J, Zancanaro F, Marino M. Lipid synthesis in the NRC-1 and SkCha-1 cholangiocytes. DDW 2002. Gastroenterology 2002; (suppl) 123; 1 :64.
8. Elli L, Maieron R, Marino M, Panos J, Andreoli S, Macor C, Zoratti L, Berretti D, Zilli M. Celiac disease and intestinal metaplasia of the oesophagus. 10th UEGW (Geneva). Gut 2002
9. D. Berretti, M. Marino et al. Percutaneous Endoscopic Gastrostomy: a review of indications, complications and outcome. Digestive and Liver Disease, volume 37, supplement 1, March 2005, S173
10. Macor, D. Berretti, M. Marino, R. Maieron, S. Pevere, P. Rossitti, L. Zoratti and M. Zilli. Successful management of bleeding duodenal varices by endoscopic injection of N-butyl-2-cyanoacrylate (glubran 2). Digestive and Liver Disease, Volume 38, Supplement 1, April 2006, Pages S52-S53
11. D. Berretti, M. Marino, C. Macor, R. Maieron, S. Pevere, P. Rossitti, L. Zoratti and M. Zilli Successful endoscopic clipping of rectal dieulafoy's lesion: Case report. Digestive and Liver Disease, Volume 38, Supplement 1, April 2006, Page S211.
12. M. Marino, D. Berretti, C. Macor, R. Maieron, S. Pevere, P. Rossitti, L. Zoratti and M. Zilli. Perforation of the esophagus after pneumatic dilatation treatment of esophageal stricture in a patient with eosinophilic esophagitis. Digestive and Liver Disease 2008. 40(1), 2008, Page S79
13. D. Berretti, M. Marino, C. Macor, R. Maieron, S. Pevere, P. Rossitti, L. Zoratti, M. Zilli. Prospective evaluation of argon plasma coagulator in therapeutic gastrointestinal endoscopy. Digestive and Liver Disease, Volume 40, Supplement 1, March 2008, Pages S192-S193
14. D. Berretti, M. Marino, C. Macor, R. Maieron, S. Pevere, P. Rossitti, L. Zoratti, M. Zilli. Argon plasma coagulator as first-line treatment for chronic radiation proctitis. Digestive and Liver Disease, Volume 40, Supplement 1, March 2008, Page S159
15. V. Ciardo, M. Zilli, D. Berretti, C. Macor, R. Maieron, M. Marino, S. Pevere, P. Rossitti, L. Zoratti Intragastric balloon for morbid obesity: a retrospective evaluation of efficacy and tolerance. Digestive and Liver Disease, Volume 40, Supplement 1, March 2008, Page S167
16. Marino M. et al. Endosonographic diagnosis of gastrointestinal stromal tumors associated with Carney Triad. Case report oral presentation at UEGW 2009 – London.
17. M. Marino, F. Grimaldi, D. Berretti, E. Tonutti, D Visentini, A. Trianni, M. Zilli. Is ghrelin a potential tumor marker in neuroendocrine tumors? European Journal of Clinical Investigation 2010; 40 (suppl 1): 1-23
18. A. Balzano, F. Manguso, V. Annese, A. Benedetti, A. D'arienzo, M. Marino, M. Alberici, G. Van Assche, R. Sablich. Oral treatment of mild to moderate ulcerative colitis with beclomethasone dipropionate or prednisone. a double-blind randomized controlled trial. Digestive and Liver disease, volume 42, supplement 2, March 2010, page s181
19. Marino M., Berretti D., Toso F., Maieron R., Zilli M. Usefulness of ultrasound in small bowel Crohn’s disease: comparison with magnetic resonance for extension, complications and disease activity. UEGW Barcelona 2010 October 23 - 27, 2010 Barcelona/Spain. Published in Gut Supplement 2010
20. Marino M, Zucchi E., Checchin D, Lodolo I, Berretti D., Maieron R., Zilli M. Incidental Diagnosis Of Inflammatory Bowel Disease During Bowel Cancer Screening Programme In Northeast Italy. 6th Congress of ECCO - Inflammatory Bowel Diseases 2011 February 24-26, 2011 in Dublin/Ireland. Published in Journal of Crohn’s and Colitis 2011
21. M Marino, D Berretti, R Maieron, P Rossitti, M Zilli Endoscopy II: Colonoscopic adverse events during bowel cancer screening programme in north-east Italy: a preliminary report. Gut 2011;60:A195
22. E Berretti D, Pevere S, Marino M., Zucchi E., Lodolo I., Zilli M. Accuracy of endoscopic ultrasonography for re-staging rectal cancer after neoadjuvant chemoradiation therapy. Presented at FISMAD 2011, Torino. Digestive and Liver Disease
23. E. Zucchi, I. Lodolo, M. Marino, G. Terrosu, D. Berretti, D. Checchin, R. Maieron, P. Rossitti, S. Vadalà e M. Zilli. Initial experience of colon rectal cancer screening programme in a single center in Friuli Venezia Giulia (Italy). Presented at FISMAD 2011, Torino Digestive and Liver Disease
24. M Marino, D Berretti, F Toso, Z Maurizio. Inflammatory bowel disease II: Usefulness of ultrasound in small bowel Crohn's disease: comparison with magnetic resonance for extension, complications and disease activity. Gut 2011;60:A210
25. Marino M, Zucchi E., Terrosu G., Berretti D., Lodolo I., Maieron R., Zilli M. et al. Relationship among colorectal cancer, advanced histology and polyp size in patients undergoing screening colonoscopy in north eastern Italy. DDW 2011 Chicago/USA. Published on Gastroenterology 2011 vol 140, 5:s-415
26. Marco Marino, Elena Zucchi, Milutin M. Bulajic, Debora Berretti, Piera Rossitti, Maurizio Zilli. The Burden of CRC Screening: Number and Cost Estimation of Follow-up Colonoscopies During CRC Screening Program in a North-Eastern Italian Single Tertiary Center. Gastroenterology 2012 Vol. 142, Issue 5, Supplement 1, Page S-777
27. Milutin M. Bulajic, Brigita D. Smolovic, Nikola Panic, Miodrag Radunovic, Maurizio Zilli, Marco Marino, Aleksandra R. Pavlovic Markovic, Zoran Krivokapic, Mirko Bulajic, Thomas Rösch. High-Risk Group Targeting Colorectal Cancer Screening May Be More Adequate for Countries With Lower Incidence Compared With Average-Risk Population Screening: The Montenegro Experience. Gastroenterology Vol. 144 2012, Issue 5, Supplement 1, Page S-602
28. Marino, Marco; Dario Sorrentino, Scott Hauenstein, Marco Marino, Steven Lockton, Dimitra Zarifi, Tiziana Del Bianco, Sharat Singh. Low Dose Infliximab for Prevention of Postoperative Recurrence of Crohn's Disease: Long Term Follow-up and Impact of Infliximab Trough Levels and Antibodies to Infliximab. Gastroenterology 2013, Volume 144, Issue 5, Supplement 1, Page S-777
29. M Marino, E Zucchi, M Fabbro, I Lodolo, R Maieron, S Vadalà, M Zilli. Outcome of infliximab discontinuation in IBD patients and therapy rechallenging in relapsers: Single centre preliminary data S232-S233 First published online: 1 February 2014
30. Marino Marco, Terrosu, Giovanni; Macchini, Federico; Vadala' di Prampero, Salvatore Francesco; Bulajic, Milutin M.; Zilli, Maurizio. Body Mass Index As New Risk Factor for Postoperative Endoscopic Recurrence in Crohn's Disease? Gastroenterology 2016, Vol. 150, Issue 4, S993
31. R. Domenis, A. Cifu', M. Fabris, G. Scardino, M. Zilli, M. Marino, F. Curcio. Do circulating exosomes interfere with vedolizumab efficacy in IBD patients? P05 abstracts of the 14th Congress of ECCO, 2019
32. M. Fabris, F. Meroi, A. Cifu', E. Castagnaviz, F. Curcio, G. Terrosu, G. Scardino, S. F. Vadalà di Prampero, M. Marino. Preliminary Evaluation of a new immunofluorescence mosaic assay for inflammatory bowel disease diagnosis: a pilot study in Udine. P228 abstracts of the 14th Congress of ECCO, 2019
33. Domenis R., Cifù A., Fabris M., Scardino G., Zilli M., Marino M., Curcio F. “Potential Role of Exosomes in Countering Vedolizumab-Based Therapy in IBD Patients” In: The FASEB Journal (2019) vol. 33 no. 1 Supplement (496.32) ISSN: 0892-6638, Experimental biology 2019 (Orlando, Florida, April 6-9)

Chapter Book

1. De Pretis G, Brosolo P, Marino M, Minerva F, Elli L. Book Chapter “Gastroscopy diagnostic and therapeutic options”. Official relation presented at the XXV Italian National Congress of Otolaryngologist (Alessandria, 21-22 September 2001).

Also speaker at different National and Local Congresses (further detailed information on request).

Research Grants

• Cooperative Interregional Study IIIa Italia-Slovenia about Coeliac disease – European Community funds.
• In 2019 Grant from Takeda International for the project: “Potential role of exosomes in determining the different clinical response to Vedolizumab in TNFα naïve vs TNFα-exposed UC/CD patients” Tracking Number: IISR-2019-102877

Terminated Postmarketing Trial

• Post-Marketing Observational Cohort Study of Patients with Inflammatory Bowel Disease (IBD) Treated with CT-P13 in Usual Clinical Practice (CONNECT-IBD)

Terminated Randomized Controlled Trials

• Subinvestigator of REMICADECRD3001: prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE® (infliximab) and Placebo in the Prevention of Recurrence in Crohn’s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence
• Principal Investigator of CNTO1275CRD3002: A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn’s Disease (UNITI-2)
• Principal Investigator of CNTO1275CRD3001: A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to TNF Antagonist Therapy (UNITI-1)
• Principal Investigator of CNTO1275CRD3003: A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Subjects with Moderately to Severely Active Crohn’s Disease (IMUNITI)
• Principal Investigator of: A Randomised Dose-Optimisation Study to Evaluate the Efficacy and Safety of Cobitolimod in Moderate to Severe Active Ulcerative Colitis Patients (Phase IIb)
• Principal Investigator of: Phase III, randomized, multicenter double-blind, double-dummy study to evaluate the efficacy and safety of etrolizumab compared with infliximab in patients with moderate to severe active ulcerative colitis who are naive to TNF inhibitors

Ongoing Randomized Controlled Trials

• Principal Investigator of TRIDENT: a Phase 2b, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Protocol to Evaluate the Safety and Efficacy of JNJ-64304500 in Subjects with Moderately to Severely Active Crohn’s Disease (Protocol 64304500CRD2001; Phase 2b JNJ-64304500)
• Principal Investigator of STARDUST: Study of Treat to Target Versus Routine Care Maintenance Strategies in Crohn’s Disease Patients Treated with Ustekinumab. PROTOCOL NUMBER: CNTO1275CRD3005
• Principal Investigator of TIGENIX: a phase III, randomized, double blind, parallel group, placebo controlled, international, multicentre study to assess efficacy and safety of Cx601, adult allogeneic expanded adipose-derived stem cells (eASC), for the treatment of complex perianal fistula(s) in patients with Crohn’s disease over a period of 24 weeks and a follow-up period up to 52 weeks. ADMIRE-CD II study
• Principal Investigator of VIBRATO: a phase 2b, double-blind, randomized, placebo-controlled, parallel group, dose ranging study of oral pf-06651600 and pf-06700841 as induction and chronic therapy in subjects with moderate to severe ulcerative colitis
• Principal Investigator of LUCENT 1: Protocol I6T-MC-AMAN. A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis
• Principal Investigator of LUCENT 2: Protocol I6T-MC-AMBG. A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis
• Principal Investigator of Yellowstone: induction study #1 - a phase 3, multicenter, randomized, double-blind, placebo-controlled study of oral ozanimod as induction therapy for moderately to severely active Crohn’s disease
• Principal Investigator of Yellowstone: a phase 3, multicenter, randomized, double-blind, placebo-controlled study of oral ozanimod as maintenance therapy for moderately to severely active Crohn’s disease
• Principal Investigator of Yellowstone: a phase 3, open label extension of study of oral ozanimod for moderately to severely active Crohn’s disease
• Principal Investigator of GALAXI: A Phase 2/3, Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Multicenter Protocol to Evaluate the Efficacy and Safety of Guselkumab in Participants with Moderately to Severely Active Crohn's Disease
• Principal Investigator of: a phase II, randomized, parallel-group, double-blind, double-dummy, placebo-controlled, multicenter study to evaluate the efficacy, safety, and pharmacokinetics of UTTR1147a compared with placebo and compared with vedolizumab in patients with moderate to severe ulcerative colitis

Conferences/Meetings Attended

1. “Acute and Chronic Pancreatitis: actual therapy” 6/6/1998 - General Hospital of Udine (Italy)
2. “Acute Pancreatitis” Villa Manin – Passariano (UD) – 9-10 June 2000
3. “8th UNITED EUROPEAN GASTROENTEROLOGY WEEK” Brussels 2000 (Belgium)
4. Course for gastroenterology specializzandi, Chianciano Terme, 28-29 September 2000
5. “Atelier; food and wellness” 29-30 September 2000 - Chianciano Terme (Italy)
6. “Has liver transplant modified the management of the cirrhotic patient?” Prof. A. K. Burroughs - General Hospital of Udine (Italy) 14 November 2000
7. “EVIDENCE-BASED Gastroenterology; III° course” Torgiano (Italy) 10-12 December 2000
8. “GEEMO Meeting 2001 & Postgraduate Course On Esophageal Disease” Abano Terme (Italy) 29-31 March 2001
9. “36th Annual Meeting of EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER” 18-22 April 2001 (Prague - CZ)
10. “Percutaneous Endoscopic gastrostomy: indications and techniques” Monfalcone (Italy), 11 May 2001
11. “Update on esophageal motility” Gastroenterology and Endoscopic Unit of Istituto S. Raffaele of Milan (ITALY) 31 June–2 July 2001
12. “GERD: a further progress to understand the disease” Rome, 29 September 2001
13. First joined workshop on therapeutic endoscopy (Torino-Toronto). Torino (Italy) 13-15 September 2001
14. “Familial adenomatous polyposis” Gastroenterology Unit – Hospital of Aviano (Italy) 12 October 2001
15. “2° Internal Medicine Congress of Friuli Venezia Giulia” General Hospital of Gemona (Italy) 13 October 2001
16. Prevention and Therapy of chronic viral hepatitis. Verona (Italy), 9 February 2002
17. Colon Cancer: mini invasive surgery? Udine (Italy), 25 May 2002
18. Chronic Hepatitis C: diagnostic and therapeutic update. Udine (Italy), 14 September 2002
19. GERD and miniinvasive treatment (laparoscopic and robotic management). Magnano in Riviera (Italy), 28 September 2002
20. Digestive Disease Week. New Orleans (USA), May 15-20, 2004
21. “XVI Symposium. IBD: from pathogenesis to clinical practice.” Padua (ITALY), January 28-29, 2005
22. “EUS and ERCP: an integrated future? A 2005 Consensus”. Reggio Emilia, 18-19 February 2005
23. UEGW 2005 – Denmark
24. UEGW 2006 – Berlin
25. DDW 2009 – Chicago
26. ECCO 2009 - Wien
27. UEGW 2009 – London
28. UEGW 2010 – New Orleans
29. ECCO – Dublin 2011
30. DDW 2011 – Chicago
31. DDW 2012
32. UEG 2013
33. UEG 2014
34. ECCO 2015 Barcelona, Spain
35. UEGW 2015 Barcelona, Spain
36. UEGW 2016 Wien, Austria
37. ECCO 2018, Wien, Austria
38. ECCO 2019 Copenhagen, Denmark
39. ECCO 2020 Wien, Austria

References

• Franco Bazzoli – Professor of Gastroenterology - franco.bazzoli@unibo.it
• Debora Berretti – Senior staff Specialist in Gastroenterology – University General Hospital of Udine – Italy. berretti.debora@aoud.sanita.fvg.it
• Prof. Janusz Jankowski - Consultant in Medicine, University Hospitals of Leicester NHS Trust, Honorary Consultant in Gastroenterology, Oxford Radcliffe Hospitals Trust – janusz.jankowski@clinpharm.ox.ac.uk
• Peter Wurm – Consultant in Gastroenterology – University Hospital of Leicester (UK) - peter.wurm@uhl-tr.nhs.uk
• Dario Sorrentino - CARILION CLINIC GASTROENTEROLOGY, 3 Riverside Circle, Roanoke, VA 24016 – USA - drsorrentino@carilionclinic.org

Udine, 4th Mar 2020

Dr. Marino Marco