Peyronie rischio tumori
Buongiorno,
mi è stata diagnosticata mesi fa la malattia di LaPeyronie (a 1/3 prossimale, placca calcifica di 1,54 x 2,02 cm., restringimento a clessidra ). Attualmente la situazione si è stabilizzata con un incurvamento di circa 30°, situazione che non mi comporta particolari problemi per quanto riguarda la mia vita sessuale, nè particolari dolori.
Ho letto ieri di questo studio (link sotto) effettuato da ricercatori dell'American Society for Reproductive Medicine di Houston, in Texas, dal quale sembra che le persone affette da questa malattia abbiano un'elevata probabilità di contrarre alcuni tipi di tumore.
Vorrei chiedervi:
1) se questo studio è attendibile o no
2) se si, a quali screening ha senso sottoporsi per prevenire eventuali patologie
3) è possibile pianificare tali screening in una struttura pubblica
4) qual' è, in questo caso, la specializzazione medica di riferimento a cui eventualmente rivolgersi.
http://www.dailymail.co.uk/health/article-5042071/Having-curved-penis-brings-higher-risk-cancer.html?ito=social-facebook
Grazie dell'attenzione
Cordiali saluti
mi è stata diagnosticata mesi fa la malattia di LaPeyronie (a 1/3 prossimale, placca calcifica di 1,54 x 2,02 cm., restringimento a clessidra ). Attualmente la situazione si è stabilizzata con un incurvamento di circa 30°, situazione che non mi comporta particolari problemi per quanto riguarda la mia vita sessuale, nè particolari dolori.
Ho letto ieri di questo studio (link sotto) effettuato da ricercatori dell'American Society for Reproductive Medicine di Houston, in Texas, dal quale sembra che le persone affette da questa malattia abbiano un'elevata probabilità di contrarre alcuni tipi di tumore.
Vorrei chiedervi:
1) se questo studio è attendibile o no
2) se si, a quali screening ha senso sottoporsi per prevenire eventuali patologie
3) è possibile pianificare tali screening in una struttura pubblica
4) qual' è, in questo caso, la specializzazione medica di riferimento a cui eventualmente rivolgersi.
http://www.dailymail.co.uk/health/article-5042071/Having-curved-penis-brings-higher-risk-cancer.html?ito=social-facebook
Grazie dell'attenzione
Cordiali saluti
[#1]
Dr. Giorgio Cavallini †
Chirurgo generale, Andrologo, Urologo
27.3k 655 55
Credo che abbia letto male. Non è presente al momento alcuna correlazione. Probabilmente si è confuso poiché quell istituto sostiene la natura tumore/simile del Peyronie e non a torto, anche se degenerazione maligna mai vists
[#2]
dopo
Utente
Gent. Dottore,
non credo di aver capito male, lo studio citato dice che
chi è affetto dalla malattia di La Peyronie ha elevate probalilità di contarre tumori al testicolo 40% e allo stomaco 29% e melanomi 40%.
Riporto sotto la sintesi tratta da Fertility and Sterility
Grazie
http://www.fertstert.org/article/S0015-0282(17)30651-9/fulltext
Peyronie′s disease (PD) is inherited in autosomal dominant fashion in a subset of men. Recent work examining genetic risk factors identified genes involved in human carcinogenesis. Here, we examine the risk of cancer among a large sample of men with PD.
Design
Retrospective cohort study.
Materials and Methods
We analyzed subjects contained within the Truven Health MarketScan claims database from 2007 to 2014. This U.S. database provides information of insurance claims filed for the care of privately-insured individuals with employment-based insurance through a participating employer. Men with PD or erectile dysfunction (ED) were identified through diagnosis (ICD-9) codes. An age and follow-up time matched control cohort of men was also created. The incidence of cancer was compared among each group utilizing a Cox regression model.
Results
In all, 48,423 men with PD, 1,177,428 with ED, and 484,230 controls were identified. The mean(SD) age among men with PD was 49.8(9.4) years, among men with ED was 48.4(9.8) years, and among controls was 49.8(9.4) years. Mean follow-up with each group was 4.5(2.0), 4.3(2.0), and 4.4(2.1) years for men with PD, ED, and controls, respectively with over 7 million total years of follow up. Men with ED had higher rates of obesity, hypertension, hyperlipidemia, smoking, or diabetes compared to men with PD and age matched controls. An increased risk of stomach cancer (HR 1.43, 95% CI 1.02-2.00), melanoma (HR 1.19, 95% CI 1.02-1.38), testis cancer (HR 1.39, 95% CI 1.05-1.84), and all cancer (HR 1.10, 95% CI 1.06-1.14) was identified among men with PD when compared with men with ED.
Conclusions
Men with PD have an increased risk of developing cancer, suggesting a possible common etiology between PD and cancer development, supporting recent genetic findings. As this is the first study to demonstrate a higher risk of cancer among men with PD, future research should focus on confirming these associations and elucidating pathways between PD and cancer. Moreover, additional follow-up of men with PD after diagnosis and treatment of PD may be warranted.
non credo di aver capito male, lo studio citato dice che
chi è affetto dalla malattia di La Peyronie ha elevate probalilità di contarre tumori al testicolo 40% e allo stomaco 29% e melanomi 40%.
Riporto sotto la sintesi tratta da Fertility and Sterility
Grazie
http://www.fertstert.org/article/S0015-0282(17)30651-9/fulltext
Peyronie′s disease (PD) is inherited in autosomal dominant fashion in a subset of men. Recent work examining genetic risk factors identified genes involved in human carcinogenesis. Here, we examine the risk of cancer among a large sample of men with PD.
Design
Retrospective cohort study.
Materials and Methods
We analyzed subjects contained within the Truven Health MarketScan claims database from 2007 to 2014. This U.S. database provides information of insurance claims filed for the care of privately-insured individuals with employment-based insurance through a participating employer. Men with PD or erectile dysfunction (ED) were identified through diagnosis (ICD-9) codes. An age and follow-up time matched control cohort of men was also created. The incidence of cancer was compared among each group utilizing a Cox regression model.
Results
In all, 48,423 men with PD, 1,177,428 with ED, and 484,230 controls were identified. The mean(SD) age among men with PD was 49.8(9.4) years, among men with ED was 48.4(9.8) years, and among controls was 49.8(9.4) years. Mean follow-up with each group was 4.5(2.0), 4.3(2.0), and 4.4(2.1) years for men with PD, ED, and controls, respectively with over 7 million total years of follow up. Men with ED had higher rates of obesity, hypertension, hyperlipidemia, smoking, or diabetes compared to men with PD and age matched controls. An increased risk of stomach cancer (HR 1.43, 95% CI 1.02-2.00), melanoma (HR 1.19, 95% CI 1.02-1.38), testis cancer (HR 1.39, 95% CI 1.05-1.84), and all cancer (HR 1.10, 95% CI 1.06-1.14) was identified among men with PD when compared with men with ED.
Conclusions
Men with PD have an increased risk of developing cancer, suggesting a possible common etiology between PD and cancer development, supporting recent genetic findings. As this is the first study to demonstrate a higher risk of cancer among men with PD, future research should focus on confirming these associations and elucidating pathways between PD and cancer. Moreover, additional follow-up of men with PD after diagnosis and treatment of PD may be warranted.
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Approfondimento su Melanoma
Il melanoma, o cancro della pelle, è un tumore, spesso molto aggressivo, che si sviluppa dalle cellule della pelle che producono melanina (melanociti).